Para Bromoanisole(PBA)

4-Bromoanisole is a clear to pale yellow liquid that serves as a versatile intermediate in organic synthesis. It is primarily utilized as a precursor for the production of pharmaceuticals, agrochemicals, and flavoring agents due to its reactive bromine substituent.

CAS No: 104-92-7

Formula

C₇H₇BrO

Main Uses

Chemical intermediate for pharmaceutical synthesis.

Appearance

Clear to pale yellow liquid.

Handling

Use fume hood; irritant/combustible.

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Safety Highlights

Personnel should review the Safety Data Sheet (SDS) to understand the specific reactivity of the ether and halide groups. While less volatile than many solvents, PBA requires careful containment to avoid environmental contamination and physical contact.

Flammable Liquid

Combustible liquid (Flash Point: 94°C); stable under normal temperatures but may decompose into toxic hydrogen bromide gas if exposed to extreme heat.

Toxic on Contact

Inhalation of high concentrations may cause respiratory tract irritation; systemic effects are generally low but prolonged exposure should be avoided.

Corrosive Agent

Acts as a moderate skin irritant and can cause redness or discomfort upon contact with the eyes.

Emergency Measures

Use water spray, alcohol-resistant foam, or dry chemical for fire suppression; ensure runoff is contained to prevent groundwater entry.

Proper Storage

Store in a cool, dark place in a tightly sealed container; keep away from strong oxidizing agents and strong bases.

Regulatory ID

UN No: 3082 (if shipped as environmentally hazardous); DOT Class: 9 (Miscellaneous).

Environmental Care

PBA is toxic to aquatic organisms; prevent any leakage into sewage systems or natural water bodies.

PPE Required

Chemical-resistant gloves (Nitrile or Neoprene) Safety goggles or face shield Protective laboratory clothing (Lab coat) Dust/Vapor respirator where airborne exposure is possible

Frequently Asked Questions

This section provides technical clarity on the chemical behavior and safety requirements of Parabromo Anisole (PBA). It serves as a guide for laboratory technicians and industrial operators to ensure compliant handling and disposal.

What are the primary industrial applications for PBA?

It is mainly used as a starting material for the synthesis of anisole-derived pharmaceuticals and as a reagent in cross-coupling chemical reactions.

Does inhaling PBA vapors pose a significant inhalation risk?

While it has a relatively low vapor pressure, breathing in concentrated mists or vapors can irritate the mucous membranes and cause coughing or shortness of breath.

What is the correct procedure for skin contact with PBA?

Wash the affected area immediately with soap and plenty of water for at least 15 minutes; seek medical advice if irritation or a rash develops.

Are there specific temperature requirements for storing PBA?

It should be stored at room temperature (ideally 15°C to 25°C) in a dry area, protected from direct sunlight to prevent degradation.

How does PBA affect the environment if a spill occurs?

It is not easily biodegradable and can bioaccumulate in aquatic environments, making rapid containment and professional remediation essential for any spill.

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