2-(1-Adamantyl)-4-bromoanisole

A high-performance crystalline intermediate engineered for advanced pharmaceutical synthesis. This specialized organic compound, also known as Adapalene Intermediate 1, is essential for the production of high-efficacy third-generation retinoids. Its unique adamantyl-substituted structure provides the critical lipophilicity required for superior dermatological and therapeutic results.

CAS No: 43109-77-9

Formula

C17H21BrO

Main Uses

Key intermediate in the synthesis of Adapalene; widely utilized in advanced organic research and API development.

Appearance

Premium-grade white to off-white crystalline powder or fine crystals.

Handling

Handle in a strictly well-ventilated area; protective measures are required to prevent skin, eye, and respiratory contact.

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Safety Highlights

Standard laboratory protocols and adherence to the Safety Data Sheet (SDS) must be strictly enforced. This compound’s bulky molecular structure ensures excellent shelf stability, but its halogenated nature requires professional management to ensure safety and environmental compliance.

Flammable Liquid

Highly stable under normal temperatures and pressures; non-flammable solid. Thermal decomposition may release toxic fumes of hydrogen bromide and carbon oxides.

Toxic on Contact

Potential irritant; may be harmful if swallowed. Inhalation of fine dust may cause localized irritation to the nose, throat, and respiratory tract.

Corrosive Agent

Classified as a Category 2 irritant; contact causes redness, itching, and inflammatory response. Use moisture-proof barriers during all handling procedures.

Emergency Measures

In case of eye contact, irrigate with water for at least 15 minutes. For fires, use water spray, dry chemical, or carbon dioxide extinguishers.

Proper Storage

Store in a cool, dry, and dark location. Keep the container hermetically sealed and protected from light to maintain peak purity levels and prevent degradation.

Regulatory ID

Not specifically listed as a high-hazard transport chemical (Non-DOT regulated), but must be managed as a professional industrial irritant.

Environmental Care

Brominated organic compounds can be persistent in the ecosystem. Do not allow material to enter drains or watercourses; dispose of through an authorized chemical waste contractor.

PPE Required

● Chemical-resistant gloves (Nitrile or Butyl rubber) ● High-clarity safety goggles or full face shield ● Industrial laboratory clothing (Anti-static, full-length lab coat) ● NIOSH-approved dust respirator (N95) during bulk weighing, sampling, or transfer

Frequently Asked Questions

Our technical experts have detailed these common questions to support your specialized manufacturing and research requirements for maximum efficiency and safety.

Why is the adamantyl group significant in this molecule?

The adamantyl group adds significant lipophilicity and structural rigidity, which are critical for the biological activity and skin-penetrating properties of the final product, Adapalene.

What are the risks of inhaling the dust?

Inhalation can cause acute irritation of the mucous membranes; it is highly recommended to handle this product within a certified fume hood or wear an N95 respirator.

What is the standard procedure for skin contact?

Immediately remove contaminated clothing and wash the affected area with copious amounts of soap and water. Seek medical advice if redness or irritation persists.

Does this product require refrigerated storage for stability?

While stable at room temperature, storing it in a cool (below 25°C), dark environment is recommended to ensure a shelf life of 2+ years without discoloration.

How does this chemical affect the environment?

As a halogenated aromatic, it is not readily biodegradable. Spill containment and proper hazardous waste disposal are essential to prevent long-term aquatic toxicity.

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