2-n-Butylbenzofuran

A high-purity heterocyclic building block for advanced molecular engineering. This alkylated benzofuran derivative is a key structural motif in the development of bioactive compounds, particularly in the synthesis of anti-arrhythmic agents and specialized organic electronic materials.

CAS No: 4265-27-2

Formula

C12H14O

Main Uses

Critical intermediate for pharmaceutical synthesis (e.g., Amiodarone analogues) and a versatile reagent in material science.

Appearance

Clear, colorless to light yellow liquid.

Handling

Use in a spark-free environment with adequate local exhaust ventilation to manage volatile organic vapors.

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Safety Highlights

Adherence to rigorous laboratory safety protocols is essential. As a substituted benzofuran, this compound is stable but requires specific storage and handling measures to mitigate its flammable and irritant properties.

Flammable Liquid

Combustible liquid; keep away from heat, sparks, and open flames. Stable under recommended storage conditions but sensitive to strong oxidizing agents.

Toxic on Contact

Inhalation of vapors may cause dizziness or respiratory tract irritation. Use only in well-ventilated areas or under a fume hood.

Corrosive Agent

Classified as an irritant. Direct contact may cause redness, drying of the skin, and significant ocular discomfort.

Emergency Measures

In case of fire, use dry chemical, CO₂, or alcohol-resistant foam. If skin contact occurs, flush with water and wash with soap immediately.

Proper Storage

Store in a cool, dry, well-ventilated area away from light and heat. Keep containers tightly closed when not in use to prevent oxidation and evaporation.

Regulatory ID

Managed as a hazardous material for transport depending on concentration; typically classified as a Class 3 Flammable Liquid (UN numbers apply for bulk).

Environmental Care

Persistent organic pollutants should be kept out of the water table. Prevent leaks into drains and dispose of via a certified hazardous waste incinerator.

PPE Required

● Chemical-resistant gloves (Nitrile or Viton) ● Safety goggles with side shields or a full face shield ● Flame-retardant laboratory coat ● Organic vapor respirator if local exhaust is insufficient

Frequently Asked Questions

Our technical team has compiled these frequently asked questions to assist in your procurement and integration processes.

What are the primary applications for 2-n-Butylbenzofuran?

It is predominantly used as a scaffold in medicinal chemistry for anti-arrhythmic drug research and as a precursor for functionalized benzofuran polymers.

Is this compound light-sensitive?

Yes, benzofuran derivatives can undergo photo-oxidation over time. It is best stored in amber glass containers or dark environments to maintain high purity.

What is the solubility profile?

It is highly soluble in common organic solvents such as ethanol, diethyl ether, and chloroform, but has negligible solubility in water.

How should a liquid spill be managed?

Absorb the spill with non-combustible material (like sand or vermiculite) and place in a sealed container for hazardous waste disposal. Avoid using sawdust or other flammable absorbers.

Does it require an inert atmosphere for storage?

While not strictly required for short-term use, blanketing the head-space with Nitrogen or Argon is recommended for long-term storage to preserve the assay.

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