5-Bromo-2-chlorobenzoic Acid(BCBA)

A high-precision building block for advanced molecular synthesis. BCBA is a critical intermediate in the pharmaceutical and agrochemical industries, valued for its dual-halogen functionality which allows for highly specific cross-coupling reactions and chemical transformations.

CAS No: 21739-92-4

Formula

C₇H₄BrClO₂

Main Uses

Intermediate for pharmaceuticals (SGLT2 inhibitors) and agrochemicals.

Appearance

Off-white to light beige crystalline powder.

Handling

Use in a controlled environment; causes skin and eye irritation.

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Safety Highlights

As a halogenated organic acid, BCBA must be handled with care to prevent exposure. Its stable crystalline structure makes it reliable for long-term storage, provided it is kept away from incompatible reactive agents.

Flammable Liquid

Non-flammable solid; stable under standard conditions. May emit toxic fumes of hydrogen bromide and hydrogen chloride upon thermal decomposition.

Toxic on Contact

Harmful if swallowed; inhalation of dust can cause irritation to the mucous membranes and upper respiratory tract.

Corrosive Agent

Classified as a Category 2 irritant; contact causes redness, pain, and potential inflammatory response in ocular tissues.

Emergency Measures

In case of fire, use water spray, alcohol-resistant foam, or dry chemical. For skin contact, remove contaminated clothing and rinse thoroughly.

Proper Storage

Store in a cool, dry, dark location. Keep the container tightly sealed to protect the integrity of the halogen bonds.

Regulatory ID

Not strictly regulated for transport in small quantities, but should be treated as a hazardous chemical (Irritant) for bulk logistics.

Environmental Care

Halogenated compounds can be persistent; avoid release into the environment. Dispose of as specialized chemical waste.

PPE Required

● Chemical-resistant gloves (Nitrile or Neoprene) ● High-clarity safety goggles or face shield ● Industrial laboratory clothing (Full-length lab coat) ● NIOSH-approved dust respirator (N95) for powder handling

Frequently Asked Questions

Our technical team provides these insights to assist in the seamless integration of BCBA into your synthetic pathways.

What are the primary applications for BCBA in drug synthesis?

It is a key starting material for various API syntheses, most notably in the production of SGLT2 inhibitors used in diabetes management.

How does the dual-halogen structure benefit chemists?

The presence of both Bromine and Chlorine allows for selective “ortho” and “meta” substitutions, giving chemists precise control over molecular architecture.

What is the best way to manage a powder spill?

Carefully sweep up the powder using a vacuum or damp cloth to avoid raising dust. Place in a sealed container for hazardous waste disposal.

Is BCBA sensitive to light or moisture?

While relatively stable, prolonged exposure to intense UV light can cause slight degradation; storage in amber glass or opaque containers is recommended.

Can this product be used in large-scale industrial reactors?

Yes, our BCBA is produced with a consistent particle size distribution, ensuring predictable solubility and reaction kinetics in large-scale batches.

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