Methyl 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoate

A high-purity crystalline ester designed for elite pharmaceutical molecular construction. This advanced organic building block serves as the final precursor in the synthesis of Adapalene, providing the essential naphthoic acid backbone required for high-efficacy retinoid therapy.

CAS No: 106684-72-2

We supply both Fresh and Pharma Pass grades based on your requirements

Formula

C29H30O3

Main Uses

Advanced intermediate for the synthesis of Adapalene (Retinoid); used in specialized pharmaceutical R&D.

Appearance

Fine white to light yellow crystalline powder.

Handling

Avoid dust inhalation and ensure skin protection during weighing and reactor charging.

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Safety Highlights

Comprehensive laboratory safety standards must be maintained according to the Safety Data Sheet (SDS). This large, stable molecule is optimized for shelf-life but requires careful handling to prevent personal exposure and maintain its high analytical purity

Flammable Liquid

Stable under recommended storage conditions; non-flammable solid. May produce carbon oxides upon thermal decomposition.

Toxic on Contact

Stable under recommended storage conditions; non-flammable solid. May produce carbon oxides upon thermal decomposition.

Corrosive Agent

Classified as a Category 2 irritant; prolonged contact may cause mild dermatitis or ocular redness.

Emergency Measures

In case of fire, use water spray, alcohol-resistant foam, or dry chemical. For eye exposure, rinse immediately with plenty of water.

Proper Storage

Store in a cool, dry, and dark environment. Keep the container tightly sealed to prevent moisture absorption and ensure long-term stability.

Regulatory ID

Not regulated as a dangerous good for transport (Non-DOT/IATA); however, it should be labeled as a professional-grade chemical irritant.

Environmental Care

While less mobile due to high molecular weight, do not release into the environment. Dispose of via incineration at a licensed chemical waste facility.

PPE Required

● Chemical-resistant gloves (Nitrile) ● Safety glasses with side shields or goggles ● Laboratory coat (Standard or anti-static) ● Dust mask or respirator (N95) for handling bulk powder

Frequently Asked Questions

Our technical experts provide these insights to ensure the successful application of this naphthoate ester in your synthetic processes.

What is the primary role of this methyl ester in drug synthesis?

It is the immediate precursor to Adapalene; the ester group is typically hydrolyzed to the carboxylic acid in the final step of the API synthesis

What are the risks of inhaling this crystalline powder?

Fine particles can irritate the mucous membranes of the lungs and throat; always perform transfers inside a ventilated enclosure or wear respiratory protection.

How should accidental skin contact be managed?

Wash the area thoroughly with soap and water. Although it is not highly corrosive, removing the chemical quickly prevents potential irritation.

Is this compound sensitive to high temperatures during storage?

It is thermally stable, but storage above 30°C for long periods is discouraged to maintain the highest possible assay and prevent any color change.

How does this chemical behave in the environment?

Due to its high lipophilicity (adamantyl and naphthyl groups), it has low water solubility and should be managed carefully to avoid soil contamination.

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