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N,N-Dimethylformamide dimethyl acetal (DMF-DMA)

Colorless liquid and reactive acetal used as a laboratory chemical/reagent. Highly flammable; vapors can form explosive mixtures. Causes serious eye damage, may cause allergic skin reaction, and is harmful if inhaled.

CAS No: 4637-24-5
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Formula

C5H13NO2

Main Uses

intermediate in organic synthesis

Appearance

Colorless liquid, odorless

Handling

Handle in well-ventilated areas

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Safety Highlights

Classified as a flammable liquid and vapor (Category 2), serious eye damage (Category 1), skin sensitizer (Category 1), and has acute inhalation toxicity (vapors Category 4) under OSHA HazCom/GHS.

Flammable Liquid

Classified as Flammable Liquid Category 2; vapors may form explosive mixtures with air and can flash back to ignition sources.

Toxic on Contact

Causes serious eye damage (Category 1), may cause allergic skin reaction (Category 1), and harmful if inhaled (Acute Inhalation Toxicity Category 4).

Corrosive Agent

Not classified as corrosive to metals, but causes severe eye irritation/damage and can irritate skin.

Emergency Measures

Rinse with water for several minutes, remove contacts if present, continue rinsing, and seek immediate medical attention.

Proper Storage

Store in a tightly closed container in a cool, well-ventilated, flammables-designated area.

Regulatory ID

CAS No: 4637-24-5 | Formula: C₅H₁₃NO₂ | Classified under OSHA HazCom/GHS as Flammable Liquid

Environmental Care

Do not release to the environment. Prevent spills from entering drains, waterways, or soil.

PPE Required

Flame-resistant lab coat, chemical-resistant gloves, eye/face protection, and organic vapor respirator

Frequently Asked Questions

Outlines DMF-DMA’s primary hazards, safe storage requirements, required PPE, spill cleanup procedures, and fire response guidance in a quick-reference format.
What are the primary hazards of DMF-DMA?
It is highly flammable, causes serious eye damage, can sensitize skin, and is harmful if inhaled. Vapors at high concentration can produce dizziness, headache, and nausea. Proper controls are essential.
How should DMF-DMA be stored?
In a tightly closed container in a cool, well-ventilated, flammables-designated area. Protect from ignition sources and keep equipment grounded to avoid static discharge.
Use chemical-resistant gloves, safety goggles/face shield, protective clothing, and, if exposure is possible, a respirator with appropriate organic vapor/particulate filters. Ensure adequate ventilation.
What should I do in case of a spill?
Eliminate ignition sources, ventilate area, and absorb with inert material. Place waste in suitable closed containers for disposal. Avoid breathing vapors and prevent release to drains.
How is fire involving DMF-DMA handled?
Extinguish using CO₂, dry chemical, or foam. Firefighters must wear self-contained breathing apparatus and full PPE due to possible release of toxic combustion products (NOx, CO, CO₂).