Acetonitrile (ACN)

Acetonitrile (ACN) is a clear, colorless, and volatile liquid with an ether-like odor. It is commonly used as a polar aprotic solvent in chemical synthesis, chromatography, and pharmaceutical manufacturing.

CAS No: 75-05-8

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Formula

C₂H₃N

Main Uses

Pharmaceuticals, Laboratory Chemicals

Appearance

Colorless, volatile liquid

Handling

Flammable – Use caution

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Safety Highlights

Acetonitrile is a hazardous, flammable, and toxic chemical that requires proper handling and protective measures. Exposure may cause serious health effects via inhalation, skin contact, or ingestion.

Flammable Liquid

Flash point at 2°C. Forms explosive vapor-air mixtures. Keep away from open flames, sparks, and heat sources.

Toxic on Contact

Harmful if swallowed, inhaled, or absorbed through the skin. Use proper PPE and ventilation

Corrosive Agent

Causes serious eye irritation. Avoid splashes and wear eye protection.

Emergency Measures

In case of fire, use water, CO₂, dry powder, or foam. Avoid use of water jets. Vapors may back-flash.

Proper Storage

Store in a cool, well-ventilated, flammable liquids-approved area. Keep containers tightly sealed and away from ignition sources.

Regulatory ID

CAS No: 75-05-8 | UN No: UN1648 | DOT/ADR Hazard Class: 3 (Flammable) | Packaging Group: II

Environmental Care

Harmful to aquatic organisms. Prevent product from entering drains or waterways.

PPE Required

Use butyl-rubber or chloroprene gloves, chemical goggles, flame-resistant clothing, and A-type respirator for organic vapors.

Frequently Asked Questions

Find clear answers to the most common questions about Acetonitrile (ACN)—its industrial uses, health hazards, safe storage, emergency response, and environmental impact. These FAQs are based on verified data and help ensure safe, compliant handling in any setting.

What is Acetonitrile used for?

Acetonitrile is widely used as a solvent in pharmaceutical synthesis, DNA sequencing, and HPLC analysis in laboratories.

Is Acetonitrile hazardous to human health?

Yes. It is harmful if inhaled, ingested, or comes into contact with skin. It also causes serious eye irritation. Always use proper protective equipment.

How should Acetonitrile be stored safely?

Store in a tightly sealed container in a cool, ventilated area designated for flammable liquids. Keep away from heat, sparks, and open flames.

What should I do in case of a spill or exposure?

Evacuate the area, ventilate, and contain the spill using absorbent material. Seek medical attention if exposed and consult the SDS for emergency protocols.

Is Acetonitrile environmentally safe?

No. It is harmful to aquatic life and should not be released into the environment. Always dispose of according to local hazardous waste regulations.

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